Purinergic Regulation of Endothelial Barrier Function
نویسندگان
چکیده
منابع مشابه
Regulation of vascular endothelial barrier function.
The increase in endothelial permeability in response to inflammatory mediators such as alpha-thrombin and histamine is accompanied by cell rounding and interendothelial gap formation, implicating that the predominant transport pathway is a diffusive one [i.e., via cellular junctions (paracellular transport)]. However, the possible contribution by vesicle-mediated transport (i.e., via albumin bi...
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SERUM IS KNOWN TO CONTAIN heat-stable and trypsinsensitive bioactive factors that possess diverse biological activities, including promotion of wound healing and tissue regeneration as well as inflammatory processes. To date, some of these factors are identified to be lysophospholipid ligands [i.e., lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P)] that bind with high affinity to a...
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Although loss of endothelial barrier function is a hallmark of every acute inflammation and contributes to fatal loss of organ function during severe infections, there is no sufficient therapy for stabilization of endothelial barrier function. Endogenous peptide adrenomedullin (AM) serum levels were shown to be increased during severe infection including sepsis and septic shock. In different in...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22031207